Rat models of major neurodegenerative disorders
نویسندگان
چکیده
No single animal model can recapitulate all the features of a particular human disease on its own. Historically, rats have been used to study neurobiology and underlying functional networks. Likewise, rat models created neurodegenerative mechanisms therapeutic interventions. In last decades, shift towards use mice has observed in many research fields, not least because comparatively easier genetic manipulation mice. However, with full sequence genome being available, advances rat, advanced test regimens biomarkers at hand, presents itself once more as valuable organism for studying disorders. This review provides an overview currently well-characterized Alzheimer’s disease, Parkinson’s Huntington’s well their advantages disorders evaluating
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ژورنال
عنوان ژورنال: Ageing and neurodegenerative diseases
سال: 2022
ISSN: ['2769-5301']
DOI: https://doi.org/10.20517/and.2022.19